Trimethoprim-sulphamethoxazole in typhoid.

Trimethoprim and sulphamethoxazole in typhoid fever in children.

One hundred and three children with proved typhoid fever were treated with trimethoprim-sulphamethoxazole, and the results compared with those of a further 40 children treated with chloramphenicol. The bacteriological response to trimethoprim-sulphamethoxazole was unsatisfactory. From this study it seems that at present chloramphenicol is still the treatment of choice for typhoid fever. In view...

Effect of trimethoprim-sulphamethoxazole on typhoid and salmonella carriers.

Four chronic typhoid carriers from the Aberdeen typhoid outbreak of 1964 were treated with trimethoprim-sulphamethoxazole. The male carrier remained clear of infection following treatment but the three female carriers, all with gall bladder abnormalities, remained excretors. A convalescent typhoid excretor also remained clear of infection after treatment as well as two other salmonella carriers...

Trimethoprim-sulphamethoxazole in enteric fevers.

Clinical improvement was rapid in all 13 patients with enteric fever and one with Brucella abortus infection treated with trimethoprim-sulphamethoxazole. There were no side-effects of the treatment and it was found easy to administer to toxic and delirious patients.

Treatment of chancroid. A comparison of sulphamethoxazole and trimethoprim-sulphamethoxazole.

Since sulphonamides are no longer predictably effective in the treatment of chancroid the combination of trimethoprim-sulphamethoxazole (TMP-SMX) was evaluated to identify other effective regimens. One hundred and nine patients with genital ulcers (75 men and 34 women) seen at the Special Treatment Clinic in Nairobi, Kenya, were randomly assigned to treatment with a seven day course of either s...

Trimethoprim-sulphamethoxazole in pertussis: comparison with tetracycline.